Steve Makofsky blogs about what he thinks is the best Home Page – The Furrygoat Experience: The Best Home Page.
Yup. A blank page. Loads fast, never 404′s and there’s no ads. Perfection.
Instructions: type "about:blank" (without the quotes) into the location bar in IE or FireFox and set it to your Home Page. Visit Tools > Options… in FireFox or Tools > Internet Options… in IE to change your Home Page setting.